dla niecierpliwych - plan badan naukowych Monachium/Londyn

o'bey · Gość

Tu macie plan badan Monachium/Londyn:

The study design consists of two parts:

• Part 1 is a brain imaging study using Arterial Spin Labeling (pCASL)
• Part 2 is a prospective, randomized, single-blinded, monocentric, placebo-controlled, cross-over, mechanistic study of VS pharmacology.

Part 1 - We will collect a group of subjects who have visual snow according to the criteria recently published by the study authors. We will do arterial spin labeling at rest to identify areas of hyperperfusion in visual snow when compared to a control group with migraine. Further, the effect of saline-infusion on the pattern of perfusion will be assessed. These results will be compared to the PET findings in an earlier study investigating visual snow patients.

Part 2 - We will administer different well-characterized medications to observe changes in clinical symptoms. Patients will receive ketamine, flumazenil, Naloxone and diazepam in a randomized order during visits 3, 4, 5 and 6. This will allow us to assess the response to receptor-specific stimulation or inhibition to understand the pharmacology behind the syndrome.

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